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Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/mL in pH 5.2 water. Its octanol: water partition .Aug 29, 2017 Sibutramine was withdrawn from the U.S. market in October 2010. Sibutramine affects chemicals in the brain that affect weight maintenance.Introduction. Sibutramine is a serotonin and norepinephrine reuptake inhibitor which has been used for short- and long-term therapy of obesity, but which was .May 19, 2004 Each MERIDIA capsule contains 5 mg, 10 mg, and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive ingredients: .The US FDA asked the manufacturer to pull the weight-loss medication from the market after clinical trial data pointed to a 16% increase in the risk for serious .

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